Osmotic stress signaling and osmoadaptation in yeasts. Adaptation of microorganisms to cold temperatures, weak acid preservatives, low pH, and osmotic stress: a review. Diagnosing oxidative stress in bacteria: not as easy as you might think. Information on valuation, funding, cap tables, investors, and executives for TAGR (Business/Productivity Software). Metabolic engineering of acid resistance elements to improve acid resistance and propionic acid production of Propionibacterium jensenii. Guan N, Li J, Shin HD, Du G, Chen J, Liu L. Microbial response to environmental stresses: from fundamental mechanisms to practical applications. Our research provides a new perspective on the optimization and reconstruction of industrial actinomycetes.ĭNA methylome Streptomyces rosesosporus TagR WTA ABC transport system daptomycin environmental stress resistance regulator. The TagR-WTA transporter regulatory pathway improved the resistance and antibiotic yield of strains and has the potential for wide application. IMPORTANCE This study established a novel strategy for screening regulators of environmental stress resistance based on the DNA methylome and discovered a new regulator, TagR. Furthermore, this research provides a new perspective on the optimization of industrial actinomycetes. This research confirmed the feasibility and effectiveness of mining regulators of environmental stress resistance based on the DNA methylome, characterized the mechanism of TagR, and improved the resistance and daptomycin yield of strains. Moreover, enhancing the expression of the WTA transporter resulted in better osmotic stress resistance in Streptomyces lividans TK24, indicating the potential for wide application of the TagR-WTA transporter regulatory pathway. Enter your email for a 30-day free trial. It consists of a temporal self-attention (TSA) module. Powered by the leader of digital pricing, discover how thousands of small business owners save time and money with the Tagr Digital Pricing Solution. The Δ tagR mutant exhibited better hyperosmotic resistance and higher decanoic acid tolerance than the wild type, which led to a 100% increase in the yield of daptomycin. Download scientific diagram The structure of temporal attention guided graph relation (TAGR) module. Further study showed that TagR had a positive self-regulatory loop and m4C methylation in the promoter improved its expression. A series of in vivo and in vitro experiments identified TagR as a negative regulator, and it is the first reported regulator of the wall teichoic acid (WTA) ABC transport system. ![]() Based on DNA methylome analysis and KEGG pathway assignment in Streptomyces roseosporus, we discovered an environmental stress resistance regulator, TagR. ![]() The origins of TaGr are unknown, though most fanfictions involve Tak. However, research on strain optimization utilizing DNA methylation for breakthroughs is rare. TaGR stands for Tak and Gaz Romance, a fictional romance from the show Invader Zim. DNA methylation is a defense that microorganisms use against extreme environmental stress, and improving resistance against environmental stress is essential for industrial actinomycetes.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |